Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Michael T. Cook; Sarah L. Smith; Vitaliy V. Khutoryanskiy

doi:10.1039/c5cc02428e

Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Michael T. Cook
, Sarah L. Smith
, Vitaliy V. Khutoryanskiy

Centre for Research into Topical Drug Delivery and Toxicology

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

228 Downloads (Pure)

Abstract

Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion

Original language	English
Pages (from-to)	14447-14450
Journal	Chemical Communications
Volume	51
Early online date	21 Jul 2015
DOIs	https://doi.org/10.1039/c5cc02428e
Publication status	E-pub ahead of print - 21 Jul 2015

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10.1039/c5cc02428eLicence: CC BY

Published VersionFinal published version, 1.45 MBLicence: CC BY

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title = "Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing",

abstract = "Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion",

author = "Cook, \{Michael T.\} and Smith, \{Sarah L.\} and Khutoryanskiy, \{Vitaliy V.\}",

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N2 - Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion

AB - Glycopolymer hydrogels capable of mimicking mucosal tissue in mucoadhesion testing have been designed. Liquid formulations containing mucoadhesive polymers were found to be retained on these tissues to the same extent as ex vivo gastric mucosa, when using a dynamic method of assessing mucoadhesion

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JO - Chemical Communications

JF - Chemical Communications

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Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing

Abstract

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