Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA

Agnieszka Pisarska, Paolo Deluca, Zsolt Demetrovics, John Corkery, Jacek Moskalewicz, ReDNet Group, Ornella Corazza, John Corkery, Jacqueline Stair, Suzanne Fergus, Cinzia Pezzolesi, Fabrizio Schifano

Research output: Contribution to journalArticlepeer-review

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Abstract

Dopamine D 3 receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of schizophrenia) differs from the other two partial agonist antipsychotics aripiprazole and brexpiprazole due to its unique features. Cariprazine is a dopamine D 3 preferring D 3/D2 partial agonist with very similar dopamine receptor sub-type selectivity as dopamine. It has proven efficacy in the treatment of positive and negative symptoms of schizophrenia, as well as for relapse prevention. Further phase-3 clinical studies proved the efficacy of cariprazine in the acute treatment of manic or mixed episodes associated with bipolar I disorder, as well as in bipolar depression. For the adjunctive treatment of major depressive disorder, phase 3 studies are in progress.
Original languageEnglish
Pages (from-to)152-163
Number of pages11
JournalNeuropsychopharmacologia Hungarica
Volume21
Issue number3
Publication statusPublished - 18 Feb 2020

Keywords

  • novel psychoactive substances
  • drugs
  • addiction
  • delegalisation
  • international study
  • Predominant negative symptoms
  • Atypical antipsychotic
  • Cariprazine
  • Schizophrenia
  • Dopamine D and D receptor partial agonist

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