Novel Viroid‐Like RNAs Naturally Infect a Filamentous Fungus

Kaili Dong, Chuan Xu, Ioly Kotta‐Loizou, Jingjing Jiang, Ruiying Lv, Linghong Kong, Shifang Li, Ni Hong, Guoping Wang, Robert H. A. Coutts, Wenxing Xu

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Abstract

To date, viroids have been found to naturally infect only plants, resulting in substantial losses for some crops. Whether viroids or viroid‐like RNAs naturally infect non‐plant hosts remains unknown. Here the existence of a set of exogenous, single‐stranded circular RNAs, ranging in size from 157 to 450 nucleotides, isolated from the fungus Botryosphaeria dothidea and nominated B. dothidea RNAs (BdcRNAs) is reported. BdcRNAs replicate autonomously in the nucleus via a rolling‐circle mechanism following a symmetric pathway. BdcRNA infection induces symptoms, because BdcRNAs can apparently modulate, to different degrees, specific biological traits (e.g., alter morphology, decrease growth rate, attenuate virulence, and increase or decrease tolerance to osmotic and oxidative stress) of the host fungus. Overall, BdcRNAs have genome characteristics similar to those of viroids and exhibit pathogenic effects on fungal hosts. It is proposed that these novel fungus infecting RNAs should be termed mycoviroids. BdcRNA(s) may be considered additional inhabitants at the frontier of life in terms of genomic complexity, and represent a new class of acellular entities endowed with regulatory functions, and novel epigenomic carriers of biological information.
Original languageEnglish
Article number2204308
Number of pages16
JournalAdvanced Science
Volume10
Issue number3
Early online date14 Dec 2022
DOIs
Publication statusE-pub ahead of print - 14 Dec 2022

Keywords

  • Research Article
  • Research Articles
  • circular RNA
  • fungus
  • mycoviroid
  • viroid
  • viroid‐like
  • viroid-like

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