Nuclear reaction rates determine the abundances of isotopes in stellar burning processes. A multitude of reactions determine the reaction flow pattern which is described in terms of reaction network simulations. The reaction rates are determined by laboratory experiments supplemented by nuclear reaction and structure theory. We will discus the experimental approach as well as the theoretical tools for obtaining the stellar reaction rates. A detailed analysis of a reaction is only possible for a few selected cases which will be highlighted in this section. The bulk of nuclear reaction processes is however described in terms of a statistical model approach, which relies on global nuclear structure and reaction parameters such as level density and mass and barrier penetration, respectively. We will discuss a variety of experimental facilities and techniques used in the field, this includes low energy stable beam experiments, measurements at radioactive beam accelerators, and neutron beam facilities.