Obsessive-compulsive disorder

Lior Carmi, Naomi Fineberg, Oded Ben-Arush, Joseph Zohar

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Introduction: Up to the early 1980s, obsessive–compulsive disorder (OCD) was considered a rare (less than 0.5%) treatment-refractory, chronic condition of psychological origin. Dynamic psychotherapy was widely used and yet had little benefit; this was also the case for pharmacological interventions [1].The observation that clomipramine, a tricyclic drug for depression with a serotonergic profile, is effective in treating symptoms of OCD [2, 3] has increased clinical interest in this disorder, including its epidemiology; several researchers have since reported a prevalence of OCD of about 2% in the general population [4, 5]. However, changes to the diagnostic system, especially the addition of OCD-related disorders (OCRDs) to OCD (and creating the OCRD cluster) [6], have dramatically increased the calculated prevalence of this cluster to close to 9%.
Original languageEnglish
Title of host publicationNew Oxford Textbook of Psychiatry
EditorsJohn Geddes, Nancy Andreasen, Guy Goodwin
PublisherOxford University Press (OUP)
ISBN (Print)9780198713005
Publication statusPublished - 9 Apr 2020


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