Oct-1, to go or not to go? That is the PolII question

Research output: Contribution to journalReview articlepeer-review

Abstract

The Oct transcription factors recognise an octamer DNA element from which they regulate transcription of specific target genes. Oct-1 is the only member of the subfamily that is ubiquitously expressed and has a wide role in transcriptional control. Through interaction with various partner proteins, Oct-1 can modulate accessibility to the chromatin to recruit the transcription machinery and form the pre-initiation complex. The recruited PolII is induced to initiate transcription and stalled until elongation is triggered on interaction with signalling transcription factors. In this way, Oct-1 can fulfil general roles in transcription by opening the chromatin as well as transduce extracellular signals by relaying activation through various interacting partners. The emerging picture of Oct-1 is that of a complex and versatile transcription factor with fundamental functions in cell homeostasis and signal response in general as well as cell specific contexts. This article is part of a Special Issue entitled: The Oct Transcription Factor Family, edited by Dr. Dean Tantin.

Original languageEnglish
Pages (from-to)820-4
Number of pages5
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1859
Issue number6
DOIs
Publication statusPublished - Jun 2016

Keywords

  • Animals
  • Chromatin/chemistry
  • Chromatin Assembly and Disassembly
  • Eukaryotic Cells/cytology
  • Gene Expression Regulation
  • Humans
  • Jumonji Domain-Containing Histone Demethylases/genetics
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics
  • Octamer Transcription Factor-1/genetics
  • Protein Binding
  • RNA Polymerase II/genetics
  • Signal Transduction
  • Transcription, Genetic

Fingerprint

Dive into the research topics of 'Oct-1, to go or not to go? That is the PolII question'. Together they form a unique fingerprint.

Cite this