Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement

P. Woo; N. Wilkinson; A-M. Prieur; T. Southwood; V. Leone; P. Livermore; H. Wythe; D. Thomson; T. Kishimoto

doi:10.1186/ar1826

Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement

P. Woo
, N. Wilkinson
, A-M. Prieur
, T. Southwood
, V. Leone
, P. Livermore
, H. Wythe
, D. Thomson
, T. Kishimoto

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

72 Downloads (Pure)

Original language	English
Journal	Arthritis Research and Therapy
Volume	7
Issue number	6
DOIs	https://doi.org/10.1186/ar1826
Publication status	Published - 2005

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Woo, P., Wilkinson, N., Prieur, A.-M., Southwood, T., Leone, V., Livermore, P., Wythe, H., Thomson, D., & Kishimoto, T. (2005). Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. Arthritis Research and Therapy, 7(6). https://doi.org/10.1186/ar1826

Woo, P. ; Wilkinson, N. ; Prieur, A-M. et al. / Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. In: Arthritis Research and Therapy. 2005 ; Vol. 7, No. 6.

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title = "Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement",

author = "P. Woo and N. Wilkinson and A-M. Prieur and T. Southwood and V. Leone and P. Livermore and H. Wythe and D. Thomson and T. Kishimoto",

note = "This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Original article can be found at: http://arthritis-research.com/",

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Woo, P, Wilkinson, N, Prieur, A-M, Southwood, T, Leone, V, Livermore, P, Wythe, H, Thomson, D & Kishimoto, T 2005, 'Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement', Arthritis Research and Therapy, vol. 7, no. 6. https://doi.org/10.1186/ar1826

Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. / Woo, P.; Wilkinson, N.; Prieur, A-M. et al.
In: Arthritis Research and Therapy, Vol. 7, No. 6, 2005.

Research output: Contribution to journal › Article › peer-review

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AU - Wythe, H.

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AU - Kishimoto, T.

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Woo P, Wilkinson N, Prieur AM, Southwood T, Leone V, Livermore P et al. Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement. Arthritis Research and Therapy. 2005;7(6). doi: 10.1186/ar1826