Opto-thermal measurement of barrier cream residence time on skin in-vivo

X. X. Guo, L. I. Ciortea, Robert Chilcott, R. E. Imhof, P. Xiao

Research output: Contribution to journalArticlepeer-review


We report the non-invasive opto-thermal measurement of the residence time of a barrier cream on in-vivo skin. These measurements revealed an approximately exponential decrease of cream layer thickness with a 1/e disappearance time of similar to 60 minutes. Measurements on a cream layer on a polymer substrate under otherwise similar conditions confirmed that penetration into the stratum corneum, rather than abrasion or evaporative loss, was the main cause of the observed disappearance.

Original languageEnglish
Pages (from-to)S346-S348
Number of pages3
JournalAnalytical Sciences
Publication statusPublished - 2001




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