TY - JOUR
T1 - Ownership illusions in patients with body delusions:
T2 - Different neural profiles of visual capture and disownership
AU - Martinaud, Olivier
AU - Besharati, Sahba
AU - Jenkinson, Paul
AU - Fotopoulou, Aikaterini
N1 - © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) funded by European Research Council.
The version of record, Martinaud, O., et al., 'Ownership illusions in patients with body delusions: Different neural profiles of visual capture and disownership,' Cortex, Vol 87, Special Issue, pp. 174-185, first published online 19 October 2016, is available online at doi: http://dx.doi.org/10.1016/j.cortex.2016.09/025
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The various neurocognitive processes contributing to the sense of body ownership have been investigated extensively in healthy participants, but studies in neurological patients can shed unique light into such phenomena. Here, we aimed to investigate whether visual capture by a fake hand (without any synchronous or asynchronous tactile stimulation) affects body ownership in a group of hemiplegic patients with or without disturbed sensation of limb ownership (DSO) following damage to the right hemisphere. We recruited 31 consecutive patients, including seven patients with DSO. The majority of our patients (64.5% overall and up to 86% of the patients with DSO) experienced strong feelings of ownership over a rubber hand within 15 sec following mere visual exposure, which correlated with the degree of proprioceptive deficits across groups and in the DSO group. Using voxel-based lesion-symptom mapping analysis, we were able to identify lesions associated with this pathological visual capture effect in a selective fronto-parietal network, including significant voxels (p < .05) in the frontal operculum and the inferior frontal gyrus. By contrast, lesions associated with DSO involved more posterior lesions, including the right temporoparietal junction and a large area of the supramarginal gyrus, and to a lesser degree the middle frontal gyrus. Thus, this study suggests that our sense of ownership includes dissociable mechanisms of multisensory integration.
AB - The various neurocognitive processes contributing to the sense of body ownership have been investigated extensively in healthy participants, but studies in neurological patients can shed unique light into such phenomena. Here, we aimed to investigate whether visual capture by a fake hand (without any synchronous or asynchronous tactile stimulation) affects body ownership in a group of hemiplegic patients with or without disturbed sensation of limb ownership (DSO) following damage to the right hemisphere. We recruited 31 consecutive patients, including seven patients with DSO. The majority of our patients (64.5% overall and up to 86% of the patients with DSO) experienced strong feelings of ownership over a rubber hand within 15 sec following mere visual exposure, which correlated with the degree of proprioceptive deficits across groups and in the DSO group. Using voxel-based lesion-symptom mapping analysis, we were able to identify lesions associated with this pathological visual capture effect in a selective fronto-parietal network, including significant voxels (p < .05) in the frontal operculum and the inferior frontal gyrus. By contrast, lesions associated with DSO involved more posterior lesions, including the right temporoparietal junction and a large area of the supramarginal gyrus, and to a lesser degree the middle frontal gyrus. Thus, this study suggests that our sense of ownership includes dissociable mechanisms of multisensory integration.
KW - anosognosia for hemiplegia
KW - Asomatognosia
KW - Motor awareness
KW - Sense of body ownership
KW - Rubber hand illusion
KW - Visual capture
KW - Interoception
KW - Proprioception
KW - Insula
KW - Premotor cortex
U2 - 10.1016/j.cortex.2016.09.025
DO - 10.1016/j.cortex.2016.09.025
M3 - Article
SN - 0010-9452
VL - 87
SP - 174
EP - 185
JO - Cortex
JF - Cortex
ER -