Palmitoyl carnitine: an endogenous promoter of calcium efflux from rat heart mitochondria

A. R. Baydoun; A. Markham; R.M. Morgan; A.J. Sweetman

doi:10.1016/0006-2952(88)90307-3

Palmitoyl carnitine: an endogenous promoter of calcium efflux from rat heart mitochondria

A. R. Baydoun, A. Markham, R.M. Morgan, A.J. Sweetman

Research output: Contribution to journal › Article › peer-review

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Abstract

The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5–40 μM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P < 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 ± 0.11 μM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10–100 μM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+---Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.

Original language	English
Pages (from-to)	3103-3107
Journal	Biochemical Pharmacology
Volume	37
Issue number	16
DOIs	https://doi.org/10.1016/0006-2952(88)90307-3
Publication status	Published - 1988

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@article{35d4b36cd25045dca51a58bf5e968b60,

title = "Palmitoyl carnitine: an endogenous promoter of calcium efflux from rat heart mitochondria",

abstract = "The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5–40 μM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P < 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 ± 0.11 μM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10–100 μM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+---Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.",

author = "Baydoun, {A. R.} and A. Markham and R.M. Morgan and A.J. Sweetman",

note = "Original article can be found at: http://www.sciencedirect.com/science/journal/00062952 Copyright Elsevier Inc. DOI: 10.1016/0006-2952(88)90307-3 [Full text of this article is not available in the UHRA]",

year = "1988",

doi = "10.1016/0006-2952(88)90307-3",

language = "English",

volume = "37",

pages = "3103--3107",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier",

number = "16",

}

TY - JOUR

T1 - Palmitoyl carnitine

T2 - an endogenous promoter of calcium efflux from rat heart mitochondria

AU - Baydoun, A. R.

AU - Markham, A.

AU - Morgan, R.M.

AU - Sweetman, A.J.

N1 - Original article can be found at: http://www.sciencedirect.com/science/journal/00062952 Copyright Elsevier Inc. DOI: 10.1016/0006-2952(88)90307-3 [Full text of this article is not available in the UHRA]

PY - 1988

Y1 - 1988

N2 - The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5–40 μM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P < 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 ± 0.11 μM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10–100 μM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+---Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.

AB - The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5–40 μM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P < 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 ± 0.11 μM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10–100 μM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+---Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.

U2 - 10.1016/0006-2952(88)90307-3

DO - 10.1016/0006-2952(88)90307-3

M3 - Article

SN - 0006-2952

VL - 37

SP - 3103

EP - 3107

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 16

ER -

Palmitoyl carnitine: an endogenous promoter of calcium efflux from rat heart mitochondria

Abstract

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