Parasite interaction with host complement: beyond attack regulation

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Many orthologous proteins of known mammalian receptors have been discovered in parasites. Besides disguising the parasite as self in terms of the host immune system, evidence is accumulating that these receptors link to signalling pathways in parasites that appear to be involved in their growth or development. Recently, several proteins of the host complement system, which forms part of the innate defence against invading microorganisms, have been shown to possess alternative functions. These complement proteins interact with signalling pathways involved in early development and differentiation, as well as organ and tissue regeneration. By altering cellular interactions and responses, complement is being shown to have novel roles besides the originally described inflammatory role. The possibility exists that, as for other host factors interacting with parasites and affecting their growth or development, host complement proteins could also have such an influence.

Original languageEnglish
Pages (from-to)407-12
Number of pages6
JournalTrends in Parasitology
Issue number9
Publication statusPublished - Sept 2004


  • Animals
  • Complement Activation
  • Complement System Proteins
  • Host-Parasite Interactions
  • Humans
  • Molecular Mimicry
  • Protozoan Proteins
  • Receptors, Complement
  • Schistosoma
  • Schistosomiasis
  • Signal Transduction
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review


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