PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

Keyphrases

• PARK2 100%
• Adenoma 100%
• Mutant Mice 100%
• Sporadic Colorectal Cancer 100%
• Adenomatous Polyposis Coli 20%
• Copy number Variation 20%
• DNA Copy number 20%
• Juvenile Parkinsonism 10%
• Exon 3 10%
• Proliferation in Vitro 10%
• Overexpression 10%
• Knock-in Mouse Model 10%
• Parkin 10%
• Autosomal Recessive 10%
• Tumor Suppressor Gene 10%
• Colorectal Cancer 10%
• Human Colorectal Cancer 10%
• Cell Proliferation 10%
• Exon 4 10%
• PARK2 Gene 10%
• Colorectal Carcinogenesis 10%
• Heterozygous Knockout 10%
• Chromosome 6 10%
• E3 Ubiquitin Ligase 10%
• Intestinal Adenoma 10%
• Colorectal Carcinoma 10%
• In Cancer 10%
• Promoter Methylation 10%
• ApcMin Mouse 10%
• Haploinsufficiency 10%
• Common Fragile Sites 10%
• Array Comparative Genomic Hybridization (aCGH) 10%
• Gene Copy number Variation 10%
• Polyps 10%

Biochemistry, Genetics and Molecular Biology

• Mouse Mutant 100%
• Gene Dosage 100%
• Adenomatous Polyposis Coli 66%
• Knockout Mouse 33%
• Exon 33%
• Tumor Suppressor Gene 33%
• Ubiquitin-Conjugating Enzyme 33%
• Haploinsufficiency 33%
• Promoter Region 33%
• Autosomal Recessive Inheritance 33%
• Chromosome 6 33%
• Autosome 33%
• Carcinogenesis 33%
• Cell Proliferation 33%
• Array Comparative Genomic Hybridization 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Colorectal Carcinoma 100%
• Mouse Mutant 100%
• Adenoma 100%
• Colon Polyposis 50%
• Carcinogenesis 25%
• Polyp 25%
• Ubiquitin Protein Ligase E3 25%
• Malignant Neoplasm 25%
• Tumor Suppressor Protein 25%
• Parkinsonism 25%
• Knockout Mouse 25%