It is well-known that newborn infants are more susceptible to infection due to their immature host defence mechanisms. However, in relation to the COVID-19 virus it appears that the naivete of the neonatal immune system has afforded some protection against the inflammatory response experienced by adolescents and adults. That said, COVID-19 and the associated changes in practice and policies implemented in response to the pandemic, has had an impact on the care of the baby during the perinatal and neonatal period. This article is the second in a two-part series, focusing on important care issues relating to the newborn specifically, taken from an integrative literature review of current literature within the maternal and neonatal field. This paper analyses the emerging themes from a selection of literature to add to the developing body of knowledge; namely, newborn respiratory physiology and immunity, the importance of breastmilk, neonatal management including, preterm labour and delivery, newborn resuscitation, investigations, care of the well and unwell baby and finally, discharge home. Finally, an overview of the World Health Organization guidance will be outlined for a global view and summary.