TY - JOUR
T1 - Perinatal Outcomes in Foetuses with Increased Nuchal Translucency and Normal Karyotype: A Retrospective Study from the United Arab Emirates
AU - Khair, Howaida
AU - Hilary, Serene
AU - Al Awar, Shamsa
AU - Zareba, Kornelia
AU - Maki, Sara
AU - Sayed, Gehan
AU - Mutare, Sharon
AU - El-Hattab, Ayman
AU - Al Abrahim, Ali Hussein
PY - 2023/10/4
Y1 - 2023/10/4
N2 - This retrospective case-controlled study analysed the outcome of pregnancies with first-trimester enlarged nuchal translucency (NT) and a normal karyotype. A total of 479 pregnan-cies with first-trimester NT measurements were grouped as control (370 cases; normal NT) andstudy (109 cases; enlarged NT,≥95th percentile; with normal karyotype). Adverse outcomes in-cluded miscarriage, intrauterine foetal death, termination of pregnancy, neonatal death, and struc-tural/chromosomal/genetic abnormalities. The study was conducted between June 2016 and June2022 at the Foetal Maternal Unit of Kanad Hospital, UAE. Overall, the live birth rate in the studygroup was significantly lower (74.3%) compared to the control (94.1%, p< 0.001). All pregnancyoutcomes of this group significantly differed compared to the control. The observed miscarriagelevel was 9.2% (vs. 1.1%, p< 0.001), intrauterine foetal death was 2.8% (vs. 0%, p= 0.001), sponta-neous preterm birthwas 11% (vs. 4.9%, p= 0.020), and termination of pregnancy was 3.7% (vs. 0%,p< 0.001). The presence of foetal abnormalities was also significantly higher in the enlarged NT groupat 21% (vs. 3.3%, p< 0.001). Results indicate that enlarged NT is associated with adverse pregnancyoutcomes even when the karyotype is normal. Based on these results, a comprehensive review ofthe guidelines for counselling and managing pregnancies with enlarged NT and a normal karyotypeis recommended.
AB - This retrospective case-controlled study analysed the outcome of pregnancies with first-trimester enlarged nuchal translucency (NT) and a normal karyotype. A total of 479 pregnan-cies with first-trimester NT measurements were grouped as control (370 cases; normal NT) andstudy (109 cases; enlarged NT,≥95th percentile; with normal karyotype). Adverse outcomes in-cluded miscarriage, intrauterine foetal death, termination of pregnancy, neonatal death, and struc-tural/chromosomal/genetic abnormalities. The study was conducted between June 2016 and June2022 at the Foetal Maternal Unit of Kanad Hospital, UAE. Overall, the live birth rate in the studygroup was significantly lower (74.3%) compared to the control (94.1%, p< 0.001). All pregnancyoutcomes of this group significantly differed compared to the control. The observed miscarriagelevel was 9.2% (vs. 1.1%, p< 0.001), intrauterine foetal death was 2.8% (vs. 0%, p= 0.001), sponta-neous preterm birthwas 11% (vs. 4.9%, p= 0.020), and termination of pregnancy was 3.7% (vs. 0%,p< 0.001). The presence of foetal abnormalities was also significantly higher in the enlarged NT groupat 21% (vs. 3.3%, p< 0.001). Results indicate that enlarged NT is associated with adverse pregnancyoutcomes even when the karyotype is normal. Based on these results, a comprehensive review ofthe guidelines for counselling and managing pregnancies with enlarged NT and a normal karyotypeis recommended.
U2 - 10.3390/jcm12196358
DO - 10.3390/jcm12196358
M3 - Article
SN - 2077-0383
SP - 1
EP - 11
JO - Journal of Clinical Medicine (JCM)
JF - Journal of Clinical Medicine (JCM)
ER -