Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits

Yanjun Zhao; Raj Khengar; M.J. Traynor; Pedro  Barata; Marc Brown; Stuart Jones

doi:10.1208/s12248-012-9325-x

Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits

Yanjun Zhao, Raj Khengar, M.J. Traynor, Pedro Barata, Marc Brown, Stuart Jones

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK).

Original language	English
Pages (from-to)	218-224
Journal	AAPS PharmSciTech
Volume	14
Issue number	2
DOIs	https://doi.org/10.1208/s12248-012-9325-x
Publication status	Published - 2012

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Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits

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