Pharmacokinetics and pharmacodynamics of piroxicam in dogs

E. A. Galbraith, Quintin McKellar

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Piroxicam was administered to beagle dogs intravenously and orally at a dose rate of 0.3 mg/kg bodyweight. It had an elimination half-life of 40.2 hours, a volume of distribution of 0.29 +/- 0.02 litres/kg and a body clearance rate of 0.066 litres/hour. When administered orally it was 100 per cent bioavailable and maximum plasma concentrations were achieved quickly (3.1 +/- 1.0 hours). Piroxicam inhibited the generation of thromboxane B2 in the blood of dogs by more than 70 per cent and more than 50 per cent inhibition was maintained in most animals for 48 hours.
Original languageEnglish
Pages (from-to)561-5
Number of pages5
JournalVeterinary record
Issue number24
Publication statusPublished - Jun 1991


Dive into the research topics of 'Pharmacokinetics and pharmacodynamics of piroxicam in dogs'. Together they form a unique fingerprint.

Cite this