Pharmacokinetics of a porcine insulin zinc suspension in diabetic dogs

P.A. Graham, A.S. Nash, Quintin McKellar

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21 Citations (Scopus)


Ten dogs with naturally occurring diabetes mellitus were injected with a highly purified porcine insulin zinc suspension at a dose according to their expected requirement. Plasma insulin and glucose concentrations were measured at two-hourly intervals over 24 hours following injection. There were either one or two peaks in plasma insulin concentration: one at about four hours (mean 4.3 +/- 1.3 [SD]) and another at about 11 hours (mean 11 +/- 1.85) after the injection. The second insulin peak was seen in only eight dogs. Persistence of elevated plasma insulin concentrations ranged from 14 to 24 hours (mean 17.4 +/- 3.65). These results compare favourably with those published for other intermediate-acting insulin preparations used to treat canine diabetes mellitus and suggest that this preparation has useful properties for the successful management of many canine diabetics.
Original languageEnglish
Pages (from-to)434-438
Number of pages5
JournalJournal of Small Animal Practice (JSAP)
Issue number10
Publication statusPublished - Oct 1997




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