TY - JOUR
T1 - Pharmacology and therapeutics of nonsteroidal antiinflammatory drugs in the dog and cat 1
T2 - General pharmacology
AU - Lees, P.
AU - May, S.A.
AU - McKellar, Quintin
PY - 1991
Y1 - 1991
N2 - The inflammatory process is described with particular reference to the cardinal signs, the microcir-culatory changes and the mediators and modulators of inflammation. Mediators and modulars comprise targets for therapeutic intervention; and the arachidonic acid pathway, generating the eicosanoid group of compounds, is considered in detail. Most non-steroidal anti-inflammatory drugs (NSAIDs) of both carboxylic and enolic acid subgroups act partly and in some cases perhaps soley through inhibition of the enzyme cyclo-oxy-genase which is concerned with the generation of an important subgroup of eicosanoids, the prostaglandins. The wanted (therapeutic) and unwanted (side-effects) actions of NSAIDs are considered together with their pharmacokinetic properties. The clinical pharmacology and therapeutic uses of NSAIDs in dogs and cats are described
AB - The inflammatory process is described with particular reference to the cardinal signs, the microcir-culatory changes and the mediators and modulators of inflammation. Mediators and modulars comprise targets for therapeutic intervention; and the arachidonic acid pathway, generating the eicosanoid group of compounds, is considered in detail. Most non-steroidal anti-inflammatory drugs (NSAIDs) of both carboxylic and enolic acid subgroups act partly and in some cases perhaps soley through inhibition of the enzyme cyclo-oxy-genase which is concerned with the generation of an important subgroup of eicosanoids, the prostaglandins. The wanted (therapeutic) and unwanted (side-effects) actions of NSAIDs are considered together with their pharmacokinetic properties. The clinical pharmacology and therapeutic uses of NSAIDs in dogs and cats are described
U2 - 10.1111/j.1748-5827.1991.tb00541.x
DO - 10.1111/j.1748-5827.1991.tb00541.x
M3 - Article
SN - 1748-5827
VL - 32
SP - 183
EP - 193
JO - Journal of Small Animal Practice (JSAP)
JF - Journal of Small Animal Practice (JSAP)
IS - 4
ER -