TY - JOUR
T1 - Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults
T2 - The Food4Me study
AU - Celis-Morales, Carlos
AU - Marsaux, Cyril F M
AU - Livingstone, Katherine M
AU - Navas-Carretero, Santiago
AU - San-Cristobal, Rodrigo
AU - O'donovan, Clare B
AU - Forster, Hannah
AU - Woolhead, Clara
AU - Fallaize, Rosalind
AU - Macready, Anna L
AU - Kolossa, Silvia
AU - Hallmann, Jacqueline
AU - Tsirigoti, Lydia
AU - Lambrinou, Christina P
AU - Moschonis, George
AU - Godlewska, Magdalena
AU - Surwiłło, Agnieszka
AU - Grimaldi, Keith
AU - Bouwman, Jildau
AU - Manios, Yannis
AU - Traczyk, Iwona
AU - Drevon, Christian A
AU - Parnell, Laurence D
AU - Daniel, Hannelore
AU - Gibney, Eileen R
AU - Brennan, Lorraine
AU - Walsh, Marianne C
AU - Gibney, Mike
AU - Lovegrove, Julie A
AU - Martinez, J Alfredo
AU - Saris, Wim H M
AU - Mathers, John C
AU - Food4Me Study
N1 - This is the peer reviewed version of the following article: Carlos Celis-Morales, et al, ‘Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study’, Obesity, Vol. 24 (4): 962-969, April 2016, which has been published in final form at DOI:
https://doi.org/10.1002/oby.21422.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PY - 2016/4/24
Y1 - 2016/4/24
N2 - OBJECTIVE: To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.METHODS: Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.RESULTS: FTO genotype was associated with a higher body weight [β: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P = 0.024], BMI [β: 0.54 kg m(-2) , (0.23-0.83), P < 0.0001], and WC [β: 1.07 cm, (0.24-1.90), P = 0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P[interaction] = 0.020). Among inactive individuals, FTO increased BMI by 1.06 kg m(-2) per allele (P = 0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kg m(-2) , P = 0.388). We observed similar effects for WC (P[interaction] = 0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals.CONCLUSIONS: PA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle.
AB - OBJECTIVE: To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.METHODS: Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.RESULTS: FTO genotype was associated with a higher body weight [β: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P = 0.024], BMI [β: 0.54 kg m(-2) , (0.23-0.83), P < 0.0001], and WC [β: 1.07 cm, (0.24-1.90), P = 0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P[interaction] = 0.020). Among inactive individuals, FTO increased BMI by 1.06 kg m(-2) per allele (P = 0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kg m(-2) , P = 0.388). We observed similar effects for WC (P[interaction] = 0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals.CONCLUSIONS: PA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle.
U2 - 10.1002/oby.21422
DO - 10.1002/oby.21422
M3 - Article
C2 - 26921105
SN - 1930-7381
VL - 24
SP - 962
EP - 969
JO - Obesity
JF - Obesity
IS - 4
ER -