Physical stabilization of low-molecular-weight amorphous drugs in the solid state: a material science approach

Sheng Qi, William J. McAuley, Ziyi Yang, Pratchaya Tipduangta

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Use of the amorphous state is considered to be one of the most effective approaches for improving the dissolution and subsequent oral bioavailability of poorly water-soluble drugs. However as the amorphous state has much higher physical instability in comparison with its crystalline counterpart, stabilization of amorphous drugs in a solid-dosage form presents a major challenge to formulators. The currently used approaches for stabilizing amorphous drug are discussed in this article with respect to their preparation, mechanism of stabilization and limitations. In order to realize the potential of amorphous formulations, significant efforts are required to enable the prediction of formulation performance. This will facilitate the development of computational tools that can inform a rapid and rational formulation development process for amorphous drugs.

Original languageEnglish
Pages (from-to)817-41
Number of pages25
JournalTherapeutic Delivery
Volume5
Issue number7
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Chemistry, Pharmaceutical
  • Drug Stability
  • Molecular Weight
  • Porosity
  • Solubility

Fingerprint

Dive into the research topics of 'Physical stabilization of low-molecular-weight amorphous drugs in the solid state: a material science approach'. Together they form a unique fingerprint.

Cite this