Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier: A literature update

Sadie M.E. Swainson, Ioanna Danai Styliari, Vincenzo Taresco, Martin C. Garnett

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
20 Downloads (Pure)

Abstract

The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature.

Original languageEnglish
Article number1561
Pages (from-to)1-11
Number of pages11
JournalPolymers
Volume11
Issue number10
DOIs
Publication statusPublished - 25 Sept 2019

Keywords

  • Poly(glycerol adipate)
  • functionalization
  • polymeric platforms
  • biodegradable
  • lipase
  • Biodegradable
  • Functionalization
  • Polymeric platforms
  • Lipase

Fingerprint

Dive into the research topics of 'Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier: A literature update'. Together they form a unique fingerprint.

Cite this