Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

J. Madeira do O, R. Foralosso, G. Yilmaz, F. Mastrotto, P.J.S. King, R.M. Xerri, Y. He, C.F. van der Walle, F. Fernandez-Trillo, C. A. Laughton, Ioanna Danai Styliari, S. Stolnik, G. Mantovani

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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Abstract

Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques-DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis-and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.

Original languageEnglish
Pages (from-to)21155-21166
Number of pages12
JournalNanoscale
Volume11
Issue number44
DOIs
Publication statusPublished - 29 Oct 2019

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