Potential of a cyclone prototype spacer to improve in vitro dry powder delivery

Irene Parisini, Sean J Cheng, Digby Symons, Darragh Murnane

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
110 Downloads (Pure)

Abstract

Purpose: Low inspiratory force in patients with lung disease is associated with poor deagglomeration and high throat deposition when using dry powder inhalers (DPIs). The potential of two reverse flow cyclone prototypes as spacers for commercial carrierbased DPIs was investigated.
Methods: Cyclohaler®, Accuhaler® and Easyhaler® were tested with and without the spacers between 30-60 Lmin-1. Deposition of particles in the next generation impactor and within the devices was determined by high performance liquid chromatography.
Results: Reduced induction port deposition of the emitted particles from the cyclones was observed due to the high retention of the drug within the spacers (e.g. salbutamol sulphate (SS): 67.89 ± 6.51 % at 30 Lmin-1 in Cheng 1). Fine particle fractions of aerosol as emitted from the cyclones were substantially higher than the DPIs alone.
Moreover, the aerodynamic diameters of particles emitted from the cyclones were
halved compared to the DPIs alone (e.g. SS from the Cyclohaler® at 4 kPa: 1.08 ±
0.05 μm vs. 3.00 ± 0.12 μm, with and without Cheng 2, respectively) and unaltered with increased flow rates.
Conclusion: This work has shown the potential of employing a cyclone spacer for commercial carrier-based DPIs to improve inhaled drug delivery.
Original languageEnglish
Pages (from-to)1133-1145
JournalPharmaceutical Research
Volume31
Issue number5
Early online date1 Nov 2013
DOIs
Publication statusPublished - May 2014

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