Precision treatment in ACS – role of assessing fibrinolysis

Ying X. Gue, Young-Hoon Jeong, Mohamed Farag, Nikolaos Spinthakis, Diana Gorog

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Abstract

Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, impairment in the ability to naturally dissolve or lyse a developing thrombus, namely impaired endogenous fibrinolysis, is responsible for a major part of this residual risk regardless of optimal antiplatelet medication. Global assessment of endogenous fibrinolysis, including a point-of-care assay, can identify patients with ACS at persistent high cardiovascular risk and might play an important role in allowing the personalisation of potent antithrombotic therapy to enhance fibrinolytic status, providing precision treatment of ACS to improve long-term outcome.
Original languageEnglish
Article number929
Number of pages8
JournalJournal of Clinical Medicine (JCM)
Volume10
Issue number5
DOIs
Publication statusPublished - 1 Mar 2021

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