Prevalence of Hepatitis C viral infection in Ghana: A systematic review and meta-analysis protocol

Peter Kwabena Fosu, Gill ten Hoor, Charles Ampong Adjei, Fidelis Atibila, Robert A. C. Ruiter

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Abstract

Background Hepatitis C virus (HCV) infection remains a major public health concern for many countries. A recent survey report in Ghana revealed a national HCV prevalence rate of 4.6% in a population of 35 million but with notably higher regional variations ranging from 8.6 to 14.4%. Considering that Ghana is targeting micro-elimination of HCV as part of the STOP Hepatitis C project, it is prudent to estimate the current epidemiological burden of hepatitis C for evidence-based policymaking, public health research, and program direction. An initial search of the literature showed a previous review that spanned from 1995 to 2015. The gap of almost 10 years may not reflect the current burden of hepatitis C in Ghana, hence this review. A systematic literature search will be performed in the major electronic databases and search engines including PubMed, Embase, Web of Science, CINAHL, and African Journals Online (AJOL). There will be a search for articles reporting on the prevalence of hepatitis C in Ghana from 2016 to 2024 in these databases. The protocol is registered with PROSPERO (CRD42024592505).
Original languageEnglish
Article numbere0321483
Pages (from-to)1-7
Number of pages7
JournalPLoS ONE
Volume20
Issue number4 April
Early online date16 Apr 2025
DOIs
Publication statusPublished - Apr 2025

Keywords

  • Ghana/epidemiology
  • Hepacivirus
  • Hepatitis C/epidemiology
  • Humans
  • Meta-Analysis as Topic
  • Prevalence
  • Systematic Reviews as Topic

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