Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis

Nader Salari, Narges Sadeghi, Amin Hosseinian Far, Razie Hasheminezhad, Habibolah Khazaei, Shamarina Shohaimi, Masoud Mohammadi

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BackgroundAnkylosing Spondylitis (AS) patients face several challenges due to the nature of the disease and its physical and psychological complications. Sleep disorders are among the most important concerns. Sleep disorders can aggravate the signs and symptoms of the disease and ultimately reduce the quality of patients’ lives. This study uses a systematic review and meta-analysis to pool the reported prevalence of sleep disorders among AS patients.MethodsTo find related studies, the WoS, PubMed, ScienceDirect, Scopus, Embase, and Google Scholar databases were systematically searched without a lower time limit. Heterogeneity among the identified studies was checked using the I2 index, and the Begg and Mazumdar correlation test examined the existence of published bias. Comprehensive Meta-Analysis (v.2) software was adopted to analyze the data.ResultsIn the review of 18 studies with a sample size of 5,840, the overall pooled prevalence of sleep disorders among AS patients based on the random effects method was found to be 53% (95% CI: 44.9–61). The highest and lowest prevalence was in Egypt at 90% and Australia at 19.2%, respectively. Our meta-regression results show that with the increase in ‘sample size’ and ‘year of publication’, the overall prevalence of sleep disorders in patients with AS decreases (p 
Original languageEnglish
Article number33
Pages (from-to)1-10
Number of pages10
JournalAdvances in Rheumatology
Publication statusPublished - 19 Jul 2023


  • Ankylosing Spondylitis
  • Sleep disturbance
  • Prevalence
  • meta-analysis


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