Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells

S.M. Wileman; G.E. Mann; A. R. Baydoun

Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells

S.M. Wileman, G.E. Mann, A. R. Baydoun

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Abstract

The interactions between proinflammatory cytokines and bacterial lipopolysaccharide (LPS) on L-arginine transporter and inducible nitric oxide synthase (iNOS) activities were examined in rat cultured aortic smooth muscle cells. 2. LPS induced a concentration (0.01 - 100 μg ml-1) and time- (8 - 24 h) dependent stimulation of nitrite production which was accompanied by a parallel increase in Larginine transport.

Original language	English
Pages (from-to)	3243-3250
Journal	British Journal of Pharmacology
Volume	116
Publication status	Published - 1995

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@article{fcc29b25a20946ce8279670643c03e37,

title = "Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells",

abstract = "The interactions between proinflammatory cytokines and bacterial lipopolysaccharide (LPS) on L-arginine transporter and inducible nitric oxide synthase (iNOS) activities were examined in rat cultured aortic smooth muscle cells. 2. LPS induced a concentration (0.01 - 100 μg ml-1) and time- (8 - 24 h) dependent stimulation of nitrite production which was accompanied by a parallel increase in Larginine transport.",

author = "S.M. Wileman and G.E. Mann and Baydoun, {A. R.}",

note = "Copyright British Pharmacological Society and Nature Publishing Group",

year = "1995",

language = "English",

volume = "116",

pages = "3243--3250",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells

AU - Wileman, S.M.

AU - Mann, G.E.

AU - Baydoun, A. R.

N1 - Copyright British Pharmacological Society and Nature Publishing Group

PY - 1995

Y1 - 1995

N2 - The interactions between proinflammatory cytokines and bacterial lipopolysaccharide (LPS) on L-arginine transporter and inducible nitric oxide synthase (iNOS) activities were examined in rat cultured aortic smooth muscle cells. 2. LPS induced a concentration (0.01 - 100 μg ml-1) and time- (8 - 24 h) dependent stimulation of nitrite production which was accompanied by a parallel increase in Larginine transport.

AB - The interactions between proinflammatory cytokines and bacterial lipopolysaccharide (LPS) on L-arginine transporter and inducible nitric oxide synthase (iNOS) activities were examined in rat cultured aortic smooth muscle cells. 2. LPS induced a concentration (0.01 - 100 μg ml-1) and time- (8 - 24 h) dependent stimulation of nitrite production which was accompanied by a parallel increase in Larginine transport.

M3 - Article

SN - 0007-1188

VL - 116

SP - 3243

EP - 3250

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

ER -

Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells

Abstract

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