Pro-inflammatory cytokines and lipopolysaccharide synergize to induce L-arginine transport and iNOS activity in vascular smooth muscle cells

S.M. Wileman, G.E. Mann, A. R. Baydoun

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    Abstract

    The interactions between proinflammatory cytokines and bacterial lipopolysaccharide (LPS) on L-arginine transporter and inducible nitric oxide synthase (iNOS) activities were examined in rat cultured aortic smooth muscle cells. 2. LPS induced a concentration (0.01 - 100 μg ml-1) and time- (8 - 24 h) dependent stimulation of nitrite production which was accompanied by a parallel increase in Larginine transport.
    Original languageEnglish
    Pages (from-to)3243-3250
    JournalBritish Journal of Pharmacology
    Volume116
    Publication statusPublished - 1995

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