Probing V5/MT excitability with transcranial magnetic stimulation following visual motion adaptation to random and coherent motion

Jessica Guzman-Lopez, Juha Silvanto, Nada Yousif, Sofia Nousi, Shamim Quadir, Barry M Seemungal

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The response to stimulating the visual cortex with transcranial magnetic stimulation (TMS) depends on its initial activation state, for example, visual motion adaptation biases perceived TMS-induced phosphene characteristics (e.g., color). We quantified this state dependence by assessing the probability of reporting a phosphene (P(λ) ) with "threshold" TMS (i.e., the TMS intensity producing P(λ) = 0.5 at baseline) following visual motion adaptation to a random dot motion display. Postadaptation, P(λ) was increased, and this effect was confined to the adapted neuronal population. We then adapted subjects using a population of moving dots of fixed average motion direction with standard deviations (SD) ranging from 1° to 128° (SD fixed for a given trial). P(λ) was significantly increased at all dot motion SDs except SD = 1°. Neuronal adaptation increases the susceptibility of the neuronal population to activation by threshold intensity TMS. Thus the process of neuronal adaption is not necessarily synonymous with a downmodulation of neuronal excitability.

Original languageEnglish
Pages (from-to)200-7
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1233
DOIs
Publication statusPublished - 23 Sept 2011

Keywords

  • Adaptation, Physiological
  • Adult
  • Female
  • Humans
  • Male
  • Motion Perception
  • Ocular Physiological Processes
  • Phosphenes
  • Photic Stimulation
  • Transcranial Magnetic Stimulation
  • Visual Cortex

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