Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection: The Pivotal Role of Immune Activation and T-cell Kinetics

Andrea Hegedus, Samuel Nyamweya, Yan Zhang, Sheila Govind, Richard Aspinall, Alla Mashanova, Vincent A. A. Jansen, Hilton Whittle, Assan Jaye, Katie L Flanagan, Derek C. Macallan

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
110 Downloads (Pure)

Abstract

BACKGROUND: Many human immunodeficiency virus (HIV)-2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status.

METHODS: We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance.

RESULTS: Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4(+) and CD8(+) T-cells and TREC depletion in naive CD4(+) T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated.

CONCLUSIONS: HIV-2 non-progressors have low rates of T-cell turnover (both CD4(+) and CD8(+)) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection.

Original languageEnglish
Pages (from-to)752-61
Number of pages10
JournalJournal of Infectious Diseases
Volume210
Issue number5
Early online date5 May 2014
DOIs
Publication statusPublished - 1 Sept 2014

Fingerprint

Dive into the research topics of 'Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection: The Pivotal Role of Immune Activation and T-cell Kinetics'. Together they form a unique fingerprint.

Cite this