TY - JOUR
T1 - Protective and antigenotoxic effect of Ulva rigida C. Agardh in experimental hypothyroid
AU - Celikler, Serap
AU - Tas, Sibel
AU - Ziyanok-Ayvalik, Sedef
AU - Vatan, O.
AU - Yildiz, Gamze
AU - Ozel, M.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - The presence of chromosomal damage in bone marrow cells affected by several diseases such as thyroid, cancer etc., was detected by the micronucleus (MN) assay. The present study was designed to evaluate: i) volatile components of Ulva rigida, ii) effects of hypothyroidism on bone marrow MN frequency, iii) effects of oral administration of Ulva rigida ethanolic extract (URE) on MN frequency produced by hypothyroidism, and iv) thyroid hormone levels in normal and 6-n-Propylthiouracil (PTU)-induced hypothyroid rats. The volatile components of Ulva rigida was studied using a direct thermal desorption (DTD) technique with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOF/MS). UREadministration was of no significant impact on thyroid hormone levels in control group, while PTU administration decreased thyroid hormone levels compared to control group (p < 0.001). Moreover, UREsupplementation resulted in a significant decrease in MN frequency in each thyroid group (p < 0.0001). This is the first in vivo study that shows the strong antigenotoxic and protective effect of UREagainst the genotoxicity produced by hypothyroidism.
AB - The presence of chromosomal damage in bone marrow cells affected by several diseases such as thyroid, cancer etc., was detected by the micronucleus (MN) assay. The present study was designed to evaluate: i) volatile components of Ulva rigida, ii) effects of hypothyroidism on bone marrow MN frequency, iii) effects of oral administration of Ulva rigida ethanolic extract (URE) on MN frequency produced by hypothyroidism, and iv) thyroid hormone levels in normal and 6-n-Propylthiouracil (PTU)-induced hypothyroid rats. The volatile components of Ulva rigida was studied using a direct thermal desorption (DTD) technique with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOF/MS). UREadministration was of no significant impact on thyroid hormone levels in control group, while PTU administration decreased thyroid hormone levels compared to control group (p < 0.001). Moreover, UREsupplementation resulted in a significant decrease in MN frequency in each thyroid group (p < 0.0001). This is the first in vivo study that shows the strong antigenotoxic and protective effect of UREagainst the genotoxicity produced by hypothyroidism.
KW - antigenotoxic effect
KW - micronucleus
KW - oxidative stress
KW - thyroid
KW - Ulva rigida
KW - volatile compounds
UR - http://www.scopus.com/inward/record.url?scp=84896811476&partnerID=8YFLogxK
U2 - 10.1556/ABiol.65.2014.1.2
DO - 10.1556/ABiol.65.2014.1.2
M3 - Article
C2 - 24561891
AN - SCOPUS:84896811476
SN - 0236-5383
VL - 65
SP - 13
EP - 26
JO - Acta Biologica Hungarica
JF - Acta Biologica Hungarica
IS - 1
ER -