Regulation of ATP production by mitochondrial Ca(2+)

Andrei I Tarasov, Elinor J Griffiths, Guy A Rutter

Research output: Contribution to journalReview articlepeer-review

172 Citations (Scopus)
71 Downloads (Pure)

Abstract

Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalCell Calcium
Volume52
Issue number1
Early online date11 Apr 2012
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Adenosine Triphosphate/biosynthesis
  • Calcium/metabolism
  • Enzymes/metabolism
  • Humans
  • Insulin-Secreting Cells/metabolism
  • Mitochondria/enzymology
  • Myocytes, Cardiac/metabolism

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