Regulation of ATP production by mitochondrial Ca(2+)

Andrei I Tarasov; Elinor J Griffiths; Guy A Rutter

doi:10.1016/j.ceca.2012.03.003

Regulation of ATP production by mitochondrial Ca(2+)

Andrei I Tarasov, Elinor J Griffiths, Guy A Rutter

Research output: Contribution to journal › Review article › peer-review

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Abstract

Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.

Original language	English
Pages (from-to)	28-35
Number of pages	8
Journal	Cell Calcium
Volume	52
Issue number	1
Early online date	11 Apr 2012
DOIs	https://doi.org/10.1016/j.ceca.2012.03.003
Publication status	Published - Jul 2012

Keywords

Adenosine Triphosphate/biosynthesis
Calcium/metabolism
Enzymes/metabolism
Humans
Insulin-Secreting Cells/metabolism
Mitochondria/enzymology
Myocytes, Cardiac/metabolism

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title = "Regulation of ATP production by mitochondrial Ca(2+)",

abstract = "Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.",

keywords = "Adenosine Triphosphate/biosynthesis, Calcium/metabolism, Enzymes/metabolism, Humans, Insulin-Secreting Cells/metabolism, Mitochondria/enzymology, Myocytes, Cardiac/metabolism",

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T1 - Regulation of ATP production by mitochondrial Ca(2+)

AU - Tarasov, Andrei I

AU - Griffiths, Elinor J

AU - Rutter, Guy A

PY - 2012/7

Y1 - 2012/7

N2 - Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.

AB - Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.

KW - Adenosine Triphosphate/biosynthesis

KW - Calcium/metabolism

KW - Enzymes/metabolism

KW - Humans

KW - Insulin-Secreting Cells/metabolism

KW - Mitochondria/enzymology

KW - Myocytes, Cardiac/metabolism

U2 - 10.1016/j.ceca.2012.03.003

DO - 10.1016/j.ceca.2012.03.003

M3 - Review article

C2 - 22502861

SN - 0143-4160

VL - 52

SP - 28

EP - 35

JO - Cell Calcium

JF - Cell Calcium

IS - 1

ER -

Regulation of ATP production by mitochondrial Ca(2+)

Abstract

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