Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

A.M. Gaya; F. Daley; N. J. Taylor; G. Tozer; U Qureshi; A. Padhani; R. Barbara Pedley; R Begent; D. Wellsted; J J Stirling; G Rustin

doi:10.1038/sj.bjc.6604426

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

A.M. Gaya, F. Daley, N. J. Taylor, G. Tozer, U Qureshi, A. Padhani, R. Barbara Pedley, R Begent, D. Wellsted, J J Stirling, G Rustin

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Abstract

Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32-73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K(trans) following CA4P, and one a statistically significant fall in IAUGC(60). No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K(trans) (P=0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.

Original language	English
Pages (from-to)	321-6
Number of pages	6
Journal	British Journal of Cancer (BJC)
Volume	99
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6604426
Publication status	Published - 2008

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title = "Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study",

abstract = "Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32-73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K(trans) following CA4P, and one a statistically significant fall in IAUGC(60). No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K(trans) (P=0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.",

author = "A.M. Gaya and F. Daley and Taylor, {N. J.} and G. Tozer and U Qureshi and A. Padhani and Pedley, {R. Barbara} and R Begent and D. Wellsted and Stirling, {J J} and G Rustin",

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doi = "10.1038/sj.bjc.6604426",

language = "English",

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T1 - Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown

T2 - an exploratory study

AU - Gaya, A.M.

AU - Daley, F.

AU - Taylor, N. J.

AU - Tozer, G.

AU - Qureshi, U

AU - Padhani, A.

AU - Pedley, R. Barbara

AU - Begent, R

AU - Wellsted, D.

AU - Stirling, J J

AU - Rustin, G

PY - 2008

Y1 - 2008

N2 - Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32-73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K(trans) following CA4P, and one a statistically significant fall in IAUGC(60). No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K(trans) (P=0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.

AB - Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32-73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K(trans) following CA4P, and one a statistically significant fall in IAUGC(60). No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K(trans) (P=0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.

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EP - 326

JO - British Journal of Cancer (BJC)

JF - British Journal of Cancer (BJC)

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ER -

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

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