Role of complexes formation between drugs and penetration enhancers in transdermal delivery

B.J. Drakulić; I.O. Juranić; S. Erić; Mire Zloh

doi:10.1016/j.ijpharm.2008.06.032

Role of complexes formation between drugs and penetration enhancers in transdermal delivery

B.J. Drakulić, I.O. Juranić, S. Erić, Mire Zloh

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects

Original language	English
Pages (from-to)	40-49
Number of pages	10
Journal	International Journal of Pharmaceutics
Volume	363
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2008.06.032
Publication status	Published - 3 Nov 2008

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abstract = "The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects",

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AU - Erić, S.

AU - Zloh, Mire

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N2 - The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects

AB - The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects

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JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

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Role of complexes formation between drugs and penetration enhancers in transdermal delivery

Abstract

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