Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Liana R. Azizova; Tetiana V. Kulik; Borys B. Palianytsia; German M. Telbiz; Mykola T. Kartel

doi:10.1016/j.colsurfa.2021.127724

Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Liana R. Azizova, Tetiana V. Kulik, Borys B. Palianytsia, German M. Telbiz, Mykola T. Kartel

Research output: Contribution to journal › Article › peer-review

Abstract

Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

Original language	English
Article number	127724
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	631
DOIs	https://doi.org/10.1016/j.colsurfa.2021.127724
Publication status	Published - 20 Dec 2021
Externally published	Yes

Keywords

Adjuvants
Fourier transform infrared spectroscopy (FT-IR)
Fumed silica
Immunostimulatory agents
Muramyl dipeptide
Pyrolysis
Temperature programmed desorption mass spectrometry (TPD-MS)
β-turn

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10.1016/j.colsurfa.2021.127724

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title = "Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface",

abstract = "Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.",

keywords = "Adjuvants, Fourier transform infrared spectroscopy (FT-IR), Fumed silica, Immunostimulatory agents, Muramyl dipeptide, Pyrolysis, Temperature programmed desorption mass spectrometry (TPD-MS), β-turn",

author = "Azizova, {Liana R.} and Kulik, {Tetiana V.} and Palianytsia, {Borys B.} and Telbiz, {German M.} and Kartel, {Mykola T.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = dec,

day = "20",

doi = "10.1016/j.colsurfa.2021.127724",

language = "English",

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journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

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TY - JOUR

T1 - Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

AU - Azizova, Liana R.

AU - Kulik, Tetiana V.

AU - Palianytsia, Borys B.

AU - Telbiz, German M.

AU - Kartel, Mykola T.

PY - 2021/12/20

Y1 - 2021/12/20

N2 - Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

AB - Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

KW - Adjuvants

KW - Fourier transform infrared spectroscopy (FT-IR)

KW - Fumed silica

KW - Immunostimulatory agents

KW - Muramyl dipeptide

KW - Pyrolysis

KW - Temperature programmed desorption mass spectrometry (TPD-MS)

KW - β-turn

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U2 - 10.1016/j.colsurfa.2021.127724

DO - 10.1016/j.colsurfa.2021.127724

M3 - Article

AN - SCOPUS:85117785683

SN - 0927-7757

VL - 631

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

M1 - 127724

ER -

Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Abstract

Keywords

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