Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Liana R. Azizova; Tetiana V. Kulik; Borys B. Palianytsia; German M. Telbiz; Mykola T. Kartel

doi:10.1016/j.colsurfa.2021.127724

Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Liana R. Azizova
, Tetiana V. Kulik
, Borys B. Palianytsia
, German M. Telbiz
, Mykola T. Kartel

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

Original language	English
Article number	127724
Number of pages	8
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	631
Early online date	11 Oct 2021
DOIs	https://doi.org/10.1016/j.colsurfa.2021.127724
Publication status	Published - 20 Dec 2021

Keywords

Adjuvants
Fourier transform infrared spectroscopy (FT-IR)
Fumed silica
Immunostimulatory agents
Muramyl dipeptide
Pyrolysis
Temperature programmed desorption mass spectrometry (TPD-MS)
β-turn

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title = "Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface",

abstract = "Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.",

keywords = "Adjuvants, Fourier transform infrared spectroscopy (FT-IR), Fumed silica, Immunostimulatory agents, Muramyl dipeptide, Pyrolysis, Temperature programmed desorption mass spectrometry (TPD-MS), β-turn",

author = "Azizova, \{Liana R.\} and Kulik, \{Tetiana V.\} and Palianytsia, \{Borys B.\} and Telbiz, \{German M.\} and Kartel, \{Mykola T.\}",

note = "{\textcopyright} 2021 Elsevier B.V.",

year = "2021",

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doi = "10.1016/j.colsurfa.2021.127724",

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TY - JOUR

T1 - Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

AU - Azizova, Liana R.

AU - Kulik, Tetiana V.

AU - Palianytsia, Borys B.

AU - Telbiz, German M.

AU - Kartel, Mykola T.

PY - 2021/12/20

Y1 - 2021/12/20

N2 - Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

AB - Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

KW - Adjuvants

KW - Fourier transform infrared spectroscopy (FT-IR)

KW - Fumed silica

KW - Immunostimulatory agents

KW - Muramyl dipeptide

KW - Pyrolysis

KW - Temperature programmed desorption mass spectrometry (TPD-MS)

KW - β-turn

UR - https://www.scopus.com/pages/publications/85117785683

U2 - 10.1016/j.colsurfa.2021.127724

DO - 10.1016/j.colsurfa.2021.127724

M3 - Article

AN - SCOPUS:85117785683

SN - 0927-7757

VL - 631

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

M1 - 127724

ER -

Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Abstract

Keywords

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