Sequence determination of a quadripartite dsRNA virus isolated from Aspergillus foetidus

Zisis Kozlakidis, Noemi Herrero, Selin Ozkan, Lakkhana Kanhayuwa, Atif Jamal, Muhammad F Bhatti, Robert H.A. Coutts

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24 Citations (Scopus)


Virus infection of Aspergillus foetidus was documented over 40 years ago and was one of the first mycovirus infections described in a filamentous fungus. The virus, named Aspergillus foetidus virus (AfV), contains at least two types of icosahedral particles, called AfV-fast (-F) and AfV-slow (-S) virions, based on their relative electrophoretic mobilities. Here, we report the complete nucleotide sequence of the AfV-F genome isolated from virions purified from the prototype isolate of the fungus. The AfV-F double-stranded (ds) RNA genome is tetra-segmented, and the plus strands of each of the four segments, but not the minus strands, are polyadenylated. The organisation and sequences of the four AfV-F dsRNAs are similar to those described for Alternaria alternata virus 1, which we propose is a member of an emerging mycovirus genus ("Alternavirus") and family ("Alternaviridae"), which also includes AfV-F.
Original languageEnglish
Pages (from-to)267-72
Number of pages6
JournalArchives of Virology
Issue number1
Publication statusPublished - Jan 2013


  • Phylogeny
  • Totivirus
  • Base Sequence
  • Viral Proteins
  • Open Reading Frames
  • Molecular Sequence Data
  • Genome, Viral
  • Aspergillus
  • RNA, Viral


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