Somatic transformation in metastatic testicular germ cell tumours – A different disease entity

Anand Sharma; Constantine Alifrangis; Marina Milic; Marcia Hall; Nikhil Vasdev; Peter Wilson; Andrew Gogbashian; David Hrouda; Daniel Berney; Jonathan Shamash

doi:10.21873/anticanres.13678

Somatic transformation in metastatic testicular germ cell tumours – A different disease entity

Anand Sharma, Constantine Alifrangis, Marina Milic, Marcia Hall, Nikhil Vasdev, Peter Wilson, Andrew Gogbashian, David Hrouda, Daniel Berney, Jonathan Shamash

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew’s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.

Original language	English
Pages (from-to)	4911-4916
Number of pages	6
Journal	Anticancer Research
Volume	39
Issue number	9
DOIs	https://doi.org/10.21873/anticanres.13678
Publication status	Published - 1 Sept 2019

Keywords

Germ cell tumour
Immature teratoma
Rhabdomyosarcoma
Sarcoma
Somatic transformation

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title = "Somatic transformation in metastatic testicular germ cell tumours – A different disease entity",

abstract = "Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew{\textquoteright}s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.",

keywords = "Germ cell tumour, Immature teratoma, Rhabdomyosarcoma, Sarcoma, Somatic transformation",

author = "Anand Sharma and Constantine Alifrangis and Marina Milic and Marcia Hall and Nikhil Vasdev and Peter Wilson and Andrew Gogbashian and David Hrouda and Daniel Berney and Jonathan Shamash",

year = "2019",

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doi = "10.21873/anticanres.13678",

language = "English",

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pages = "4911--4916",

journal = "Anticancer Research",

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T1 - Somatic transformation in metastatic testicular germ cell tumours – A different disease entity

AU - Sharma, Anand

AU - Alifrangis, Constantine

AU - Milic, Marina

AU - Hall, Marcia

AU - Vasdev, Nikhil

AU - Wilson, Peter

AU - Gogbashian, Andrew

AU - Hrouda, David

AU - Berney, Daniel

AU - Shamash, Jonathan

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew’s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.

AB - Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew’s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.

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KW - Somatic transformation

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Somatic transformation in metastatic testicular germ cell tumours – A different disease entity

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