Sonographic characterisation of tissue changes associated with infused apomorphine hydrochloride – a case series

H. Edwards, L. Poltawski, A. Todd

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)
    182 Downloads (Pure)

    Abstract

    Apomorphine hydrochloride is used to treat refractory motor fluctuations in advanced Parkinson’s disease. Delivery by infusion is associated with the formation of hard subcutaneous nodules, which may be painful, limit available infusion sites, and interfere with absorption of the drug. Diagnostic ultrasound was used to image affected tissue in twelve people experiencing apomorphine nodule formations. It revealed significant departures from normality in dermal and subcutaneous tissue, including a variety of nodule appearances, dermal thickening and diffuse changes consistent with inflammatory reactions. Sonographic appearances differed markedly between individuals, but no clear correlation between severity of tissue changes, patient demographics and apomorphine dose was observed. Diagnostic ultrasound may be useful as a non-invasive method of assessing subcutaneous nodule formation, to measure changes in affected tissue over time and after treatment.
    Original languageEnglish
    Pages (from-to)155-159
    JournalUltrasound
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - Aug 2008

    Keywords

    • Ultrasound
    • Parkinson's disease
    • Focal & diffuse tissue changes
    • Dermal thickness
    • Apomorphine
    • Panniculitis

    Fingerprint

    Dive into the research topics of 'Sonographic characterisation of tissue changes associated with infused apomorphine hydrochloride – a case series'. Together they form a unique fingerprint.

    Cite this