Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women

Martin O. Weickert, Manja Reimann, Bärbel Otto, Wendy L. Hall, Katerina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Bügel, Christine M Williams, Hans-Joachim Zunft, Corinna Koebnick

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37 Citations (Scopus)
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Abstract

Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.
Original languageEnglish
Article number11
Number of pages6
JournalJournal of Negative Results in BioMedicine
Volume5
DOIs
Publication statusPublished - 2006

Keywords

  • Aged
  • Body Weight
  • Cross-Over Studies
  • Double-Blind Method
  • Fasting
  • Female
  • Ghrelin
  • Humans
  • Isoflavones
  • Middle Aged
  • Peptide Hormones
  • Peptide YY
  • Postmenopause
  • Soy Foods

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