Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women

Martin O. Weickert; Manja Reimann; Bärbel Otto; Wendy L. Hall; Katerina Vafeiadou; Jesper Hallund; Marika Ferrari; Duncan Talbot; Francesco Branca; Susanne Bügel; Christine M Williams; Hans-Joachim Zunft; Corinna Koebnick

doi:10.1186/1477-5751-5-11

Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women

Martin O. Weickert, Manja Reimann, Bärbel Otto, Wendy L. Hall, Katerina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Bügel, Christine M Williams, Hans-Joachim Zunft, Corinna Koebnick

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Abstract

Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.

Original language	English
Article number	11
Number of pages	6
Journal	Journal of Negative Results in BioMedicine
Volume	5
DOIs	https://doi.org/10.1186/1477-5751-5-11
Publication status	Published - 2006

Keywords

Aged
Body Weight
Cross-Over Studies
Double-Blind Method
Fasting
Female
Ghrelin
Humans
Isoflavones
Middle Aged
Peptide Hormones
Peptide YY
Postmenopause
Soy Foods

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10.1186/1477-5751-5-11

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© 2006 Weickert et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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Weickert, M. O., Reimann, M., Otto, B., Hall, W. L., Vafeiadou, K., Hallund, J., Ferrari, M., Talbot, D., Branca, F., Bügel, S., Williams, C. M., Zunft, H.-J., & Koebnick, C. (2006). Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. Journal of Negative Results in BioMedicine, 5, Article 11. https://doi.org/10.1186/1477-5751-5-11

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abstract = "Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut {"}satiety hormones{"} such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.",

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author = "Weickert, {Martin O.} and Manja Reimann and B{\"a}rbel Otto and Hall, {Wendy L.} and Katerina Vafeiadou and Jesper Hallund and Marika Ferrari and Duncan Talbot and Francesco Branca and Susanne B{\"u}gel and Williams, {Christine M} and Hans-Joachim Zunft and Corinna Koebnick",

note = "{\textcopyright} 2006 Weickert et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited",

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Weickert, MO, Reimann, M, Otto, B, Hall, WL, Vafeiadou, K, Hallund, J, Ferrari, M, Talbot, D, Branca, F, Bügel, S, Williams, CM, Zunft, H-J & Koebnick, C 2006, 'Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women', Journal of Negative Results in BioMedicine, vol. 5, 11. https://doi.org/10.1186/1477-5751-5-11

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AU - Weickert, Martin O.

AU - Reimann, Manja

AU - Otto, Bärbel

AU - Hall, Wendy L.

AU - Vafeiadou, Katerina

AU - Hallund, Jesper

AU - Ferrari, Marika

AU - Talbot, Duncan

AU - Branca, Francesco

AU - Bügel, Susanne

AU - Williams, Christine M

AU - Zunft, Hans-Joachim

AU - Koebnick, Corinna

N1 - © 2006 Weickert et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

PY - 2006

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N2 - Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.

AB - Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.

KW - Aged

KW - Body Weight

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Fasting

KW - Female

KW - Ghrelin

KW - Humans

KW - Isoflavones

KW - Middle Aged

KW - Peptide Hormones

KW - Peptide YY

KW - Postmenopause

KW - Soy Foods

U2 - 10.1186/1477-5751-5-11

DO - 10.1186/1477-5751-5-11

M3 - Article

C2 - 16907966

SN - 1477-5751

VL - 5

JO - Journal of Negative Results in BioMedicine

JF - Journal of Negative Results in BioMedicine

M1 - 11

ER -

Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women

Abstract

Keywords

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