Spike sorting for large, dense electrode arrays

Cyrille Rossant; Shabnam N. Kadir; Dan F.M. Goodman; John Schulman; Maximilian L.D. Hunter; Aman B. Saleem; Andres Grosmark; Mariano Belluscio; George H. Denfield; Alexander S. Ecker; Andreas S. Tolias; Samuel Solomon; György Buzski; Matteo Carandini; Kenneth D. Harris

doi:10.1038/nn.4268

Spike sorting for large, dense electrode arrays

Cyrille Rossant, Shabnam N. Kadir, Dan F.M. Goodman, John Schulman, Maximilian L.D. Hunter, Aman B. Saleem, Andres Grosmark, Mariano Belluscio, George H. Denfield, Alexander S. Ecker, Andreas S. Tolias, Samuel Solomon, György Buzski, Matteo Carandini, Kenneth D. Harris

Research output: Contribution to journal › Article › peer-review

289 Citations (Scopus)

Abstract

Developments in microfabrication technology have enabled the production of neural electrode arrays with hundreds of closely spaced recording sites, and electrodes with thousands of sites are under development. These probes in principle allow the simultaneous recording of very large numbers of neurons. However, use of this technology requires the development of techniques for decoding the spike times of the recorded neurons from the raw data captured from the probes. Here we present a set of tools to solve this problem, implemented in a suite of practical, user-friendly, open-source software. We validate these methods on data from the cortex, hippocampus and thalamus of rat, mouse, macaque and marmoset, demonstrating error rates as low as 5%.

Original language	English
Pages (from-to)	634-641
Number of pages	8
Journal	Nature Neuroscience
Volume	19
Issue number	4
DOIs	https://doi.org/10.1038/nn.4268
Publication status	Published - 29 Mar 2016

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AU - Rossant, Cyrille

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AU - Goodman, Dan F.M.

AU - Schulman, John

AU - Hunter, Maximilian L.D.

AU - Saleem, Aman B.

AU - Grosmark, Andres

AU - Belluscio, Mariano

AU - Denfield, George H.

AU - Ecker, Alexander S.

AU - Tolias, Andreas S.

AU - Solomon, Samuel

AU - Buzski, György

AU - Carandini, Matteo

AU - Harris, Kenneth D.

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Spike sorting for large, dense electrode arrays

Abstract

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