Spike-timing dependent plasticity facilitates excitatory/inhibitory disbalances in early phases of tinnitus manifestation

C. Metzner; Fabian Guth; Achim Schweikard; Bartosz Zurowski

Spike-timing dependent plasticity facilitates excitatory/inhibitory disbalances in early phases of tinnitus manifestation

C. Metzner, Fabian Guth, Achim Schweikard, Bartosz Zurowski

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Abstract

The majority of tinnitus cases are related to cochlear dysfunction, leading to altered peripheral input to the central auditory system. These alterations are
believed to diminish the difference in activation during on- and off-conditions of sound. As a compensatory means the affected region of primary auditory cortex
tries to maximize the difference between basic level activity and sound-induced activity by changing the excitatory /inhibitory balance. In a previous model comprising ~3000 multi-compartment Hodgkin-Huxley-type neurons, we have shown that solely an increase of excitatory influences may be sufficient to achieve these maximization. This previous Hodgkin-Huxley-type model did not take into account synaptic plasticity, however

Original language	English
Article number	P1
Number of pages	2
Journal	BMC Neuroscience
Volume	13
Issue number	Suppl 1
Publication status	Published - 2012

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© 2012 Metzner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Final published version, 138 KBLicence: CC BY

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403531/

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title = "Spike-timing dependent plasticity facilitates excitatory/inhibitory disbalances in early phases of tinnitus manifestation",

abstract = "The majority of tinnitus cases are related to cochlear dysfunction, leading to altered peripheral input to the central auditory system. These alterations arebelieved to diminish the difference in activation during on- and off-conditions of sound. As a compensatory means the affected region of primary auditory cortextries to maximize the difference between basic level activity and sound-induced activity by changing the excitatory /inhibitory balance. In a previous model comprising ~3000 multi-compartment Hodgkin-Huxley-type neurons, we have shown that solely an increase of excitatory influences may be sufficient to achieve these maximization. This previous Hodgkin-Huxley-type model did not take into account synaptic plasticity, however",

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AU - Metzner, C.

AU - Guth, Fabian

AU - Schweikard, Achim

AU - Zurowski, Bartosz

N1 - © 2012 Metzner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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N2 - The majority of tinnitus cases are related to cochlear dysfunction, leading to altered peripheral input to the central auditory system. These alterations arebelieved to diminish the difference in activation during on- and off-conditions of sound. As a compensatory means the affected region of primary auditory cortextries to maximize the difference between basic level activity and sound-induced activity by changing the excitatory /inhibitory balance. In a previous model comprising ~3000 multi-compartment Hodgkin-Huxley-type neurons, we have shown that solely an increase of excitatory influences may be sufficient to achieve these maximization. This previous Hodgkin-Huxley-type model did not take into account synaptic plasticity, however

AB - The majority of tinnitus cases are related to cochlear dysfunction, leading to altered peripheral input to the central auditory system. These alterations arebelieved to diminish the difference in activation during on- and off-conditions of sound. As a compensatory means the affected region of primary auditory cortextries to maximize the difference between basic level activity and sound-induced activity by changing the excitatory /inhibitory balance. In a previous model comprising ~3000 multi-compartment Hodgkin-Huxley-type neurons, we have shown that solely an increase of excitatory influences may be sufficient to achieve these maximization. This previous Hodgkin-Huxley-type model did not take into account synaptic plasticity, however

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JO - BMC Neuroscience

JF - BMC Neuroscience

IS - Suppl 1

M1 - P1

ER -

Spike-timing dependent plasticity facilitates excitatory/inhibitory disbalances in early phases of tinnitus manifestation

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