Spike-timing dependent plasticity facilitates excitatory/inhibitory disbalances in early phases of tinnitus manifestation

C. Metzner, Fabian Guth, Achim Schweikard, Bartosz Zurowski

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Abstract

The majority of tinnitus cases are related to cochlear dysfunction, leading to altered peripheral input to the central auditory system. These alterations are
believed to diminish the difference in activation during on- and off-conditions of sound. As a compensatory means the affected region of primary auditory cortex
tries to maximize the difference between basic level activity and sound-induced activity by changing the excitatory /inhibitory balance. In a previous model comprising ~3000 multi-compartment Hodgkin-Huxley-type neurons, we have shown that solely an increase of excitatory influences may be sufficient to achieve these maximization. This previous Hodgkin-Huxley-type model did not take into account synaptic plasticity, however
Original languageEnglish
Article numberP1
Number of pages2
JournalBMC Neuroscience
Volume13
Issue numberSuppl 1
Publication statusPublished - 2012

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