SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis

Keyphrases

• 3-hydroxy-3-methylglutaryl-coenzyme A 60%
• Balance Study 20%
• Beagle Dog 100%
• Bile Acid Excretion 20%
• Cholesterol 20%
• Cholesterol Biosynthesis 100%
• Cholesterol Excretion 20%
• Cholesterol Levels 40%
• Dog Model 20%
• Dual Isotopes 20%
• Endogenous Synthesis 20%
• Enhanced Degradation 20%
• HepG2 Cells 20%
• Intestinal Cholesterol Absorption 20%
• Isotope Technique 20%
• Lathosterol 20%
• Lovastatin 20%
• Low-density Lipoprotein Cholesterol (LDL-C) 20%
• Mode of Action 20%
• Normolipidemic 20%
• Plasma Cholesterol 100%
• Reductase 20%
• Reductase Inhibitors 40%
• Sterols 40%

Biochemistry, Genetics and Molecular Biology

• Absorption 20%
• Beagle 100%
• Bile Acid 20%
• Blood Plasma 20%
• Canine Model 20%
• Cholesterol Blood Level 100%
• Cholesterol Level 40%
• Cholesterol Synthesis 100%
• HMG-CoA 60%
• Isotope Technique 20%
• Lathosterol 20%
• Lovastatin 20%
• Low-Density Lipoprotein 20%
• Oxidoreductase 60%
• Reductase 60%
• Sterol 40%

Pharmacology, Toxicology and Pharmaceutical Science

• Beagle 100%
• Bile Acid 33%
• Canine Model 33%
• HMG-CoA 100%
• Lathosterol 33%
• Low Density Lipoprotein Cholesterol 33%
• Mevinolin 33%
• Oxidoreductase 100%
• Sterol 66%