Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device

Ambra Vestri; Amanda K. Pearce; Robert Cavanagh; Ioanna D. Styliari; Carlos Sanders; Benoit Couturaud; Silvia Schenone; Vincenzo Taresco; Rasmus R. Jakobsen; Steven M. Howdle; Francesca Musumeci; Domenico Sagnelli

doi:10.3390/coatings10020125

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device

Ambra Vestri, Amanda K. Pearce, Robert Cavanagh, Ioanna D. Styliari, Carlos Sanders, Benoit Couturaud, Silvia Schenone, Vincenzo Taresco, Rasmus R. Jakobsen, Steven M. Howdle, Francesca Musumeci, Domenico Sagnelli

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Abstract

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.

Original language	English
Article number	125
Number of pages	15
Journal	Coatings
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/coatings10020125
Publication status	Published - 1 Feb 2020

Keywords

Biocompatible
Biomaterial
Drug delivery
Nanocomposites
Nanoparticles
Poly(glycerol-adipate)
Polymer
Starch

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10.3390/coatings10020125Licence: CC BY

coatings-10-00125-v2
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 2.6 MBLicence: CC BY

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title = "Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device",

abstract = "Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.",

keywords = "Biocompatible, Biomaterial, Drug delivery, Nanocomposites, Nanoparticles, Poly(glycerol-adipate), Polymer, Starch",

author = "Ambra Vestri and Pearce, {Amanda K.} and Robert Cavanagh and Styliari, {Ioanna D.} and Carlos Sanders and Benoit Couturaud and Silvia Schenone and Vincenzo Taresco and Jakobsen, {Rasmus R.} and Howdle, {Steven M.} and Francesca Musumeci and Domenico Sagnelli",

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AU - Vestri, Ambra

AU - Pearce, Amanda K.

AU - Cavanagh, Robert

AU - Styliari, Ioanna D.

AU - Sanders, Carlos

AU - Couturaud, Benoit

AU - Schenone, Silvia

AU - Taresco, Vincenzo

AU - Jakobsen, Rasmus R.

AU - Howdle, Steven M.

AU - Musumeci, Francesca

AU - Sagnelli, Domenico

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PY - 2020/2/1

Y1 - 2020/2/1

N2 - Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.

AB - Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.

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JO - Coatings

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ER -

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device

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Keywords

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