Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets

Viral F. Patel; Natavarlal M. Patel

doi:10.1080/03639040601050155

Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets

Viral F. Patel, Natavarlal M. Patel

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The present investigation explored the use of xanthan gum and guar gum for development of floating drug delivery system of dipyridamole using factorial design approach. The content of polymer blends (X(1)) and ratio of xanthan gum to guar gum (X(2)) were selected as independent variables. The diffusion exponent (n), release rate constant (k), percentage drug release at 1 hr (Q(1)) and 6 hr (Q(6)) were selected as dependent variables. Tablets of all batches had desired buoyancy characteristics. Multiple regression analysis with two way ANOVA revealed that both the factors had statistically significant influence on the response studied (p

Original language	English
Pages (from-to)	327-34
Number of pages	8
Journal	Drug Development and Industrial Pharmacy
Volume	33
Issue number	3
DOIs	https://doi.org/10.1080/03639040601050155
Publication status	Published - 2007

Keywords

Analysis of Variance
Diffusion
Dipyridamole
Drug Carriers
Drug Delivery Systems
Factor Analysis, Statistical
Galactans
Mannans
Plant Gums
Polysaccharides, Bacterial
Tablets
Vasodilator Agents

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abstract = "The present investigation explored the use of xanthan gum and guar gum for development of floating drug delivery system of dipyridamole using factorial design approach. The content of polymer blends (X(1)) and ratio of xanthan gum to guar gum (X(2)) were selected as independent variables. The diffusion exponent (n), release rate constant (k), percentage drug release at 1 hr (Q(1)) and 6 hr (Q(6)) were selected as dependent variables. Tablets of all batches had desired buoyancy characteristics. Multiple regression analysis with two way ANOVA revealed that both the factors had statistically significant influence on the response studied (p",

keywords = "Analysis of Variance, Diffusion, Dipyridamole, Drug Carriers, Drug Delivery Systems, Factor Analysis, Statistical, Galactans, Mannans, Plant Gums, Polysaccharides, Bacterial, Tablets, Vasodilator Agents",

author = "Patel, {Viral F.} and Patel, {Natavarlal M.}",

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doi = "10.1080/03639040601050155",

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T1 - Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets

AU - Patel, Viral F.

AU - Patel, Natavarlal M.

PY - 2007

Y1 - 2007

N2 - The present investigation explored the use of xanthan gum and guar gum for development of floating drug delivery system of dipyridamole using factorial design approach. The content of polymer blends (X(1)) and ratio of xanthan gum to guar gum (X(2)) were selected as independent variables. The diffusion exponent (n), release rate constant (k), percentage drug release at 1 hr (Q(1)) and 6 hr (Q(6)) were selected as dependent variables. Tablets of all batches had desired buoyancy characteristics. Multiple regression analysis with two way ANOVA revealed that both the factors had statistically significant influence on the response studied (p

AB - The present investigation explored the use of xanthan gum and guar gum for development of floating drug delivery system of dipyridamole using factorial design approach. The content of polymer blends (X(1)) and ratio of xanthan gum to guar gum (X(2)) were selected as independent variables. The diffusion exponent (n), release rate constant (k), percentage drug release at 1 hr (Q(1)) and 6 hr (Q(6)) were selected as dependent variables. Tablets of all batches had desired buoyancy characteristics. Multiple regression analysis with two way ANOVA revealed that both the factors had statistically significant influence on the response studied (p

KW - Analysis of Variance

KW - Diffusion

KW - Dipyridamole

KW - Drug Carriers

KW - Drug Delivery Systems

KW - Factor Analysis, Statistical

KW - Galactans

KW - Mannans

KW - Plant Gums

KW - Polysaccharides, Bacterial

KW - Tablets

KW - Vasodilator Agents

U2 - 10.1080/03639040601050155

DO - 10.1080/03639040601050155

M3 - Article

C2 - 17454065

SN - 0363-9045

VL - 33

SP - 327

EP - 334

JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

IS - 3

ER -

Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets

Abstract

Keywords

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