Present investigation highlights the formulation and optimization of floating tablets of ranitidine hydrochloride. Formulations were optimized for type of filler, different viscosity grades of hydroxypropylmethylcellulose and its concentration.Two filler namely Avicel PH 102 and Tablettose 80 were used. Study revealed that type of filler had significant effect on release of drug from hydrophilic matrix tablets (f 2 value 41.30) and floating properties.Three different viscosity grades of hydroxypropylmethylcellulose namely K100 LV, K4M and K15M were used. It was observed that viscosity had a major influence on drug release from hydrophilic matrices as well as on floating properties. Dissolution profiles were subjected various kinetic drug release equations and found that drug release from hydrophilic matrices occurred via diffusion mechanism following square root of time profile (Higuchi equation). Optimized formulation were studied for effect of hardness on floating properties, effect of position of paddle and dissolution medium on drug release as well as accelerated short term stability study. Hardness of tablets had greater influence on floating lag time which might be due to decreased porosity. Position of paddle and types of dissolution medium had no significant effect on drug release. Optimized formulation was found to be stable at 40°/75% RH for the period of three months.
|Number of pages
|Indian Journal of Pharmaceutical Sciences
|Published - 1 Dec 2005