Synthesis, antimycobacterial activity evaluation and mode of action of series of novel diketones

Keyphrases

• β-diketone 100%
• Mode of Action 100%
• Activity Evaluation 100%
• Mode of Activity 100%
• Antimycobacterial Activity 100%
• Synthesized Compounds 75%
• Mycobacterium Bovis BCG 75%
• Resistant Strains 50%
• Scanning Electron Microscopy 50%
• Mycobacterium Smegmatis 50%
• J774A.1 50%
• New Drugs 25%
• Broth Microdilution 25%
• Structure-activity Relationship 25%
• Spectroscopic Techniques 25%
• Active Tuberculosis 25%
• Murine Macrophages 25%
• IC50 Value 25%
• In Vitro Cytotoxicity 25%
• Multidrug-resistant Infection 25%
• Whole Genome Sequencing 25%
• Extensively Drug-resistant 25%
• Morphological Changes 25%
• 13C NMR 25%
• Resistant Bacteria 25%
• J774 Macrophages 25%
• 1H nuclear Magnetic Resonance (1H NMR) 25%
• Active Compounds 25%
• XDR-tuberculosis 25%
• Mycobacterium Tuberculosis (M. tb) 25%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 25%
• MTT Assay 25%
• TDR-TB 25%
• XDR-TB 25%
• Baker-venkataraman Reaction 25%
• Multidrug-resistant 25%
• Substituted Acetophenones 25%
• Benzoyl Chloride 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Mycobacterium Bovis BCG 100%
• Antimycobacterial Agent 100%
• Infection 100%
• Diketone 100%
• Mycobacterium Smegmatis 66%
• Scanning Electron Microscopy 66%
• Lead Compound 66%
• Acetophenone Derivative 33%
• Structure Activity Relationship 33%
• Benzoyl Chloride 33%
• Tuberculosis 33%
• IC50 33%
• Dilution Assay 33%
• Extensively Drug-Resistant Tuberculosis 33%
• Carbon 13 33%
• Isoniazid 33%
• Cytotoxicity 33%