TY - JOUR
T1 - Synthesis of conformationally constrained analogues of BRL32872
T2 - Determination of stereochemistry and related pharmacological properties
AU - Souchet, M.
AU - Forest, M.-C.
AU - Cheval, B.
AU - Rouanet, S.
AU - Faivre, J.-F.
AU - Bril, A.
AU - Gerhard, U.
AU - Smith, R.J.
N1 - Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1997/8/5
Y1 - 1997/8/5
N2 - 2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.
AB - 2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.
UR - http://www.scopus.com/inward/record.url?scp=0030743297&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(97)00349-1
DO - 10.1016/S0960-894X(97)00349-1
M3 - Article
AN - SCOPUS:0030743297
SN - 0960-894X
VL - 7
SP - 1989
EP - 1994
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 15
ER -