Synthesis of conformationally constrained analogues of BRL32872: Determination of stereochemistry and related pharmacological properties

M. Souchet, M.-C. Forest, B. Cheval, S. Rouanet, J.-F. Faivre, A. Bril, U. Gerhard, R.J. Smith

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.
Original languageEnglish
Pages (from-to)1989-1994
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number15
DOIs
Publication statusPublished - 5 Aug 1997

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