Synthesis of conformationally constrained analogues of BRL32872: Determination of stereochemistry and related pharmacological properties

M. Souchet; M.-C. Forest; B. Cheval; S. Rouanet; J.-F. Faivre; A. Bril; U. Gerhard; R.J. Smith

doi:10.1016/S0960-894X(97)00349-1

Synthesis of conformationally constrained analogues of BRL32872: Determination of stereochemistry and related pharmacological properties

M. Souchet
, M.-C. Forest
, B. Cheval
, S. Rouanet
, J.-F. Faivre
, A. Bril
, U. Gerhard
, R.J. Smith

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.

Original language	English
Pages (from-to)	1989-1994
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(97)00349-1
Publication status	Published - 5 Aug 1997

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10.1016/S0960-894X(97)00349-1

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abstract = "2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.",

author = "M. Souchet and M.-C. Forest and B. Cheval and S. Rouanet and J.-F. Faivre and A. Bril and U. Gerhard and R.J. Smith",

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T1 - Synthesis of conformationally constrained analogues of BRL32872

T2 - Determination of stereochemistry and related pharmacological properties

AU - Souchet, M.

AU - Forest, M.-C.

AU - Cheval, B.

AU - Rouanet, S.

AU - Faivre, J.-F.

AU - Bril, A.

AU - Gerhard, U.

AU - Smith, R.J.

PY - 1997/8/5

Y1 - 1997/8/5

N2 - 2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.

AB - 2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.

UR - https://www.scopus.com/pages/publications/0030743297

U2 - 10.1016/S0960-894X(97)00349-1

DO - 10.1016/S0960-894X(97)00349-1

M3 - Article

AN - SCOPUS:0030743297

SN - 0960-894X

VL - 7

SP - 1989

EP - 1994

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Synthesis of conformationally constrained analogues of BRL32872: Determination of stereochemistry and related pharmacological properties

Abstract

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