Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

Keyphrases

• N-oxides 100%
• Disubstituted 100%
• Piperidone 100%
• Tumor Selectivity 100%
• Alkylation 100%
• Potential for Development 100%
• DNA Crosslinking Agents 33%
• Cytotoxic Activity 33%
• Chromophore 33%
• Human Ovarian Cancer 33%
• A2780 Cells 33%
• DNA Unwinding 33%
• DNA Interstrand Crosslinks 33%
• IC50 Value 33%
• Anthraquinone 33%
• PBR322 33%
• Side Chain 33%
• Hydroxylated 33%
• Ring Systems 33%
• Anthraquinone Derivatives 33%
• Guanine 33%
• Two-agent 33%
• Cell Line Panel 33%
• Cross-linking Activity 33%
• Derivatization 33%
• Interstrand Crosslink 33%
• GI50 33%
• Cancer Cell Lines 33%
• Halides 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Neoplasm 100%
• Ovary Cancer 50%
• Guanine 50%
• IC50 50%
• Anthraquinone 50%
• Halide 50%
• Cytotoxicity 50%